Recent advances in the neuroendocrine control of hydromineral homeostasis

30/08/2023 04:12:40 Author: Jackson Cionek

Recent advances in the neuroendocrine control of hydromineral homeostasis

Recent advances in the neuroendocrine control of hydromineral homeostasis
Recent advances in the neuroendocrine control of hydromineral homeostasis

As of my last training cut-off in September 2021, the neuroendocrine control of hydromineral homeostasis is primarily centered on the regulation of water and salt balance within the body. This regulation is crucial for maintaining blood pressure, cell function, and overall homeostasis. The system largely revolves around the brain, kidneys, and various hormones. Here are some key components and advances up until that time:

Vasopressin (Antidiuretic Hormone, ADH):

Produced by the hypothalamus and released by the posterior pituitary in response to increased plasma osmolality (detected by osmoreceptors) or decreased blood volume (detected by baroreceptors).

Acts on the kidneys to promote water reabsorption, decreasing urine volume and increasing urine concentration.

Newer research has been focused on the diverse roles of vasopressin, including its effects on social behavior and memory.

Renin-Angiotensin-Aldosterone System (RAAS):

A key system for salt and water balance and blood pressure regulation.

Starts with the release of renin from the kidneys in response to decreased blood volume or decreased sodium concentration. This leads to a cascade of events resulting in the production of angiotensin II, which has vasoconstrictive properties and stimulates the release of aldosterone from the adrenal cortex. Aldosterone promotes sodium (and consequently, water) reabsorption in the kidneys.

Atrial Natriuretic Peptide (ANP) and Brain Natriuretic Peptide (BNP):

Released from the heart in response to increased blood volume.

Acts as a diuretic by promoting sodium and water excretion in the kidneys. It also counteracts the effects of the RAAS.


TRPV4 Channels: Some research has shed light on the role of TRPV4 channels in osmosensation, which could further explain how cells detect changes in osmolality.

Aquaporins: These are water channels in cells. Aquaporin-2, in particular, plays a significant role in water reabsorption in the kidneys, and its trafficking and abundance are regulated by vasopressin.

Connectivity: Advanced imaging studies have expanded our understanding of the connectivity between osmoreceptive regions in the brain and other neural regions responsible for thirst and salt appetite.

Potential Therapeutic Implications:

Better understanding of these systems has led to new therapeutic targets, especially for conditions like heart failure, hypertension, and certain forms of kidney diseases.

It's crucial to consult current literature or experts in the field for the very latest advancements beyond 2021. The field of neuroendocrinology is rapidly evolving with the advent of new technologies and research methodologies.

Neuroscience 2023 and Artificial Intelligence

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Homeostasis Perception and Emotion in Panic

Antropologia Amerindia América Latina

Newborn Behavioral Observation

"Muscle matters: from human disease to human performance"

Transgenerational memories of trauma - epigenetic, physiological and mental health factors

Efeito de Realidade Virtual e Gamificação no Aprendizado

Vida moderna, Ritmos Biológicos, Sono, Homeostasia Fisiológica e Processos Cognitivos

Long-term cognitive and emotional impairments associated to hypercholesterolemia

Short- and long-term effects of ethanol on astrocyte functioning

Caffeine effects on brain development

Obesidade do neurodesenvolvimento ao envelhecimento

Repercussões fisiológicas e celulares da exposição aos pesticidas em períodos críticos do desenvolvimento

Distúrbios do Crescimento Celular

Maternal, Infant and Early Childhood Nutrition

Endocrine Disruptors

Cancer as a developmental disease

Scientific Question and Experimental Design

Scientific Research Integrity

Neuroscience of Obesity

Epilepsy Neuroscience and Perception

The Liver-Brain axis

A fisiologia do feminino

Active Learning to Improve Engagement

The molecular basis of Exercise-induced skeletal muscle mitochondrial biogenesis

Neurochemical Underpinnings of Psychedelic-Induced Ego Dissolution

Recent advances in the neuroendocrine control of hydromineral homeostasis

Psychoneuroimmunology Immunoneuroendocrine interactions

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Acerca da modificação de memórias episódicas

The biological response of ayahuasca

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Variabilidade da frequência cardíaca como marcador da integração neurovisceral

Inteligência artificial, psicodélicos, e saúde mental

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